Electrophysiological changes after repeated alcohol withdrawal.
نویسنده
چکیده
Studies of spontaneous and kindled electrophysiological brain activity following AW emphasize the important contribution of several variables to the severity of AW and to the associated long-lasting changes in brain function. Thus, withdrawal severity depends on the pattern of alcohol intake (e.g., withdrawal history) as well as on the total amount of alcohol exposure. Moreover, different brain regions respond differently to various patterns of alcohol exposure.
منابع مشابه
Kindling in alcohol withdrawal.
In many alcoholics, the severity of withdrawal symptoms increases after repeated withdrawal episodes. This exacerbation may be attributable to a kindling process. Kindling is a phenomenon in which a weak electrical or chemical stimulus, which initially causes no overt behavioral responses, results in the appearance of behavioral effects, such as seizures, when it is administered repeatedly. Bot...
متن کاملLong-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure.
Alcohol exposure induces multiple neuroadaptive changes in the CNS that can have serious long-term consequences on CNS function including cognitive effects and attenuation of learning and memory. The cellular mechanisms underlying the CNS effects of alcohol have yet to be fully elucidated and are likely to depend on the pattern and dose of alcohol exposure. Using electrophysiological recordings...
متن کامل[Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters].
Alcohol withdrawal is a syndrome that is the result of adaptive changes in the brain secondary to chronic alcohol use and is associated with changes in many neurotransmitter, neuropeptide, and hormonal systems. Long-term exposure to ethanol leads to an imbalance in different excitatory (especially glutamate, a major excitatory amino acid), and inhibitory neurotransmitter (especially GABA, a maj...
متن کاملWithdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro.
Changing the activity of ventral tegmental area (VTA) dopamine neurons from pacemaker to burst firing is hypothesized to increase the salience of stimuli, such as an unexpected reward, and likely contributes to withdrawal-associated drug-seeking behavior. Accordingly, pharmacological, behavioral, and electrophysiological data suggest an important role of the VTA in mediating alcohol-dependent b...
متن کاملRapid Death Due to Alcohol Withdrawal Syndrome: Case Report and Review of Literature
Background: Alcohol withdrawal syndrome (AWS) is one of the most serious complications associated with chronic alcoholism. Sudden deaths are not uncommon in AWS. In severe stages of AWS, delirium tremens (DT) occurs, which is characterized with agitation, global confusion, disorientation, visual and auditory hallucinations in addition to autonomic hyperactivity. Case report: A 30-year old man, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Alcohol health and research world
دوره 22 1 شماره
صفحات -
تاریخ انتشار 1998